Quick Reference
- Scientific Rating
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4.7/ 5.0
- Standardized Form
- Standardized extract (typically 90-95% OPCs)
Grape Seed Extract (GSE) is derived from the seeds of Vitis vinifera. It is highly concentrated in OPCs, a class of polyphenols that crosslink collagen fibers to strengthen blood vessel walls. GSE also activates endothelial nitric oxide synthase (eNOS), which improves blood flow. It is heavily utilized in clinical settings across Europe to treat chronic venous insufficiency and edema.
Table of Contents
Clinical Summary
Clinically supported for significantly reducing leg swelling (edema), improving venous tone, and modestly lowering blood pressure.
Dosage Guidelines
150mg to 300mg daily.
Safety & Side Effects
Very safe. Mild stomach ache or headache in rare cases.
Known Interactions
May theoretically increase bleeding risk if combined with blood-thinning medications.
Scientific References
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Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.